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KMID : 0880520150510020081
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Chonnam Medical Journal
2015 Volume.51 No. 2 p.81 ~ p.85
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Clinical Significance of MET Gene Copy Number in Patients with Curatively Resected Gastric Cancer
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Kang Byung-Woog
Kim Jong-Gwang
Park He-Young
Park Bo-Eun
Jeon Seong-Woo
Bae Han-Ik
Kwon Oh-Kyoung
Chung Ho-Young
Yu Wan-Sik
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Abstract
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The present study analyzed the prognostic impact of MET gene copy number in patients with curatively resected gastric cancer who received a combination regimen of cisplatin and S-1. The MET gene copy number was analyzed by use of quantitative real-time polymerase chain reaction. From January 2006 to July 2010, 70 tumor samples from 74 patients enrolled in a pilot study were analyzed. According to a cutoff MET gene copy number of ≥2 copies, a high MET gene copy number was observed in 38 patients (54.3%). The characteristics of the 2 groups divided according to MET gene copy number were similar. With a median follow-up duration of 26.4 months (range, 2.6-73.2 months), the estimated 3-year relapse-free survival and overall survival rates were 54.3% and 77.4%, respectively. No significant association was observed between the MET gene copy number and survival in a multivariate analysis. The MET gene copy number investigated in this study was not found to be associated with prognosis in patients with curatively resected gastric cancer.
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KEYWORD
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MET, Stomach neoplasms, Chemotherapy, Adjuvant, Prognosis
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